MRQLAB EXPLORATION MATRIX

Clinical Intent ➔ Physics Execution

Select a verified clinical pathology case to launch the Retromorphic Workbench instrument.

📍 Brain / White MatterFundamental

Multiple Sclerosis (MS) Plaque Contrast

Clinical Question: Why do demyelinating MS plaques appear hyperintense on T2 TSE while minimizing CSF partial volume artifacts?

Key Physics: T2 transverse relaxation differentiation + EPG stimulated echo preservation in TSE echo train

⚡ Brain T2 Turbo Spin Echo (TSE)

📍 Brain / VentriclesIntermediate

Clinical Question: How does Inversion Recovery null CSF signal to reveal periventricular lesions?

Key Physics: 180° Inversion Recovery null-crossing timing $TI = T1 \ln(2)$

⚡ T2 Fluid Attenuated Inversion Recovery

📍 Heart / Carotid ArteryAdvanced

Clinical Question: How to completely suppress flowing luminal blood signal while preserving high SNR for carotid plaque wall?

Key Physics: Double Inversion Recovery (DIR) flow dephasing + slice selective re-inversion

⚡ Dark Blood Turbo Spin Echo (Uses: TSE)

📍 MyocardiumAdvanced

Clinical Question: How to quantify diffuse interstitial fibrosis via pixel-wise T1 relaxation fitting?

Key Physics: Look-Locker readout modification with modified EPG steady-state correction

⚡ Modified Look-Locker Inversion (MOLLI)

📍 Abdomen / LiverIntermediate

Clinical Question: How does chemical shift phase cycling separate fat from water parenchymal signals?

Key Physics: 3.5 ppm chemical shift $\Delta f$ phase modulation between in-phase and out-of-phase echoes

⚡ Dual-Echo Fast Gradient Echo (GRE)

📍 Musculoskeletal / KneeFundamental

Clinical Question: How does collagen matrix degradation correlate with multi-echo T2 prolongation?

Key Physics: Multi-echo Spin Echo CPMG decay curve exponential non-linear regression

⚡ Multi-Echo Spin Echo (MESE)